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| Similar words: Autoimmune Diseases | |
| Disease Models, Autoimmune, Nervous System Autoimmune Disease Models, Nervous System | Autoimmune Myositis, Experimental | Myositis, Experimental Autoimmune | Experimental Autoimmune Myositis | Myositis, Autoimmune Experimental | Nervous System Autoimmune Disease Models Animal disease models that simulate human autoimmune disorders of the central or peripheral nervous system. Disease models have been established for the study of GUILLAIN-BARRE SYNDROME (see NEURITIS, EXPERIMENTAL ALLERGIC); MYASTHENIA GRAVIS (see MYASTHENIA GRAVIS, EXPERIMENTAL AUTOIMMUNE); and MULTIPLE SCLEROSIS (see ENCEPHALOMYELITIS, EXPERIMENTAL AUTOIMMUNE). | |
| Autoimmune Diseases Autoimmune Disease | Disease, Autoimmune | Diseases, Autoimmune Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. | |
| Purpura, Thrombocytopenic, Idiopathic Autoimmune Thrombocytopenic Purpura | Idiopathic Thrombocytopenic Purpura | Purpura, Thrombocytopenic, Autoimmune | Werlhof' | s Disease | Autoimmune Thrombocytopenia | Werlhof Disease | Autoimmune Thrombocytopenias | Disease, Werlhof Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms. | |
| Hepatitis, Autoimmune Autoimmune Hepatitis | Autoimmune Hepatitides | Hepatitides, Autoimmune An unresolving, predominately periportal, hepatitis, usually with hypergammaglobulinemia and serum autoantibodies. The existence of subgroups (types 1, 2, and 3) based on serological findings are controversial. Additionally, some patients have variant forms, where there are features associated with both autoimmune hepatitis and another type of chronic liver disease (overlap syndromes) or where there are findings incompatible with autoimmune hepatitis (outlier syndromes). (From Czaja, Ann Intern Med. 1996; 125:588-598) | |
| Polyradiculoneuropathy Autoimmune Demyelinating Disease, Peripheral | Demyelinating Autoimmune Disease, Peripheral | Demyelinating Disease, Peripheral Autoimmune | Peripheral Autoimmune Demyelinating Disease | Polyradiculoneuritis | Polyradiculoneuritides Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots. | |
| Polyendocrinopathies, Autoimmune Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy | Autoimmune Syndrome Type I, Polyglandular | Autoimmune Syndrome Type II, Polyglandular | Polyglandular Type I Autoimmune Syndrome | Schmidt' | s Syndrome Autoimmune disease affecting multiple endocrine organs. Type I is characterized by childhood onset and mucocutaneous candidiasis, while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis, hypoparathyroidism, and gonadal failure. In both types organ-specific antibodies against a variety of endocrine glands have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. | |
| Autoimmunity Autoimmune Response | Autoimmune Responses | Autoimmunities Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES. | |
| Demyelinating Autoimmune Diseases, CNS Autoimmune Demyelinating Diseases, Central Nervous System | Spinal Cord Demyelinating Autoimmune Diseases | Autoimmune Demyelinating Diseases, CNS | Autoimmune Demyelinating Diseases, Cerebral | Autoimmune Demyelinating Disorders, CNS Conditions characterized by loss or dysfunction of myelin (see MYELIN SHEATH) in the brain, spinal cord, or optic nerves secondary to autoimmune mediated processes. This may take the form of a humoral or cellular immune response directed toward myelin or OLIGODENDROGLIA associated autoantigens. | |
| Myasthenia Gravis, Experimental Autoimmune Myasthenia Gravis, Autoimmune Experimental | Passive Transfer Experimental Autoimmune Myasthenia Gravis | Autoimmune Experimental Myasthenia Gravis | Experimental Autoimmune Myasthenia Gravis, Passive Transfer | Experimental Myasthenia Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3) | |
| Addison's Disease Addison Disease | Addisons Disease | Disease, Addison | Disease, Addison' | s A disease characterized by hypotension, weight loss, anorexia, weakness, and sometimes a bronze-like melanotic hyperpigmentation of the skin. It is due to tuberculosis- or autoimmune-induced disease (hypofunction) of the adrenal glands that results in deficiency of aldosterone and cortisol. In the absence of replacement therapy, it is usually fatal. | |
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